1.
Ann Pharm Fr
; 50(3): 167-76, 1992.
Artigo
em Francês
| MEDLINE
| ID: mdl-1290386
RESUMO
HPLC have been used to validate simple methods to be employed in developing countries (DC) for the quality control of drugs. As the important lack of analytical material in DC, colorimetric methods have been used. These are subjected to visual appreciation of the color intensity. Two essential drugs have been selected: aspirin, hydrochlorothiazide. For each compound, standardization of concentration's degradation product by colorimetry and HPLC have been achieved in proximity of the restricted norms of pharmacopoeia. These results have been applied to tablets exposed to stressed conditions (t(0) = 60 and humidity = 75%). The results obtained by colorimetric method were similar to HPLC's ones.